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. 2016 Dec 19;292(5):1876–1883. doi: 10.1074/jbc.M116.748707

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FIGURE 5. — Rituximab variants RTX. SEFL1.1 or RTX.SEFL2.0 and negative control RTX.IgG2 have minimal CDC activity compared with the wild-type rituximab. Rituximab (RTX.IgG1), RTX.IgG2, RTX.SEFL1.1, and RTX.SEFL2.0 mAb at 1, 10, and 100 μg/ml were added to Raji lymphoma cells for 24 h and the percentage of cell killing measured by flow cytometric analysis after adding propidium iodide (5 μg/ml). Data points were collected in duplicate and percentage of propidium iodide-positive cells was measured against total gated cells.