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. 2016 Dec 19;292(5):1876–1883. doi: 10.1074/jbc.M116.748707

TABLE 1.

Therapeutic mAbs and variants tested for Fc binding and effector functions

Molecule name	Type
mAbV.IgG2	IgG2 isotype control
mAbX.IgG2^a	IgG2
mAbX.SEFL2.0^b	IgG1 L242C,N297G,K334C
mAbY.IgG2^c	IgG2
mAbY.IgG1	IgG1
mAbY.SEFL2.0^b	IgG1 L242C,N297G,K334C
RTX.IgG1	IgG1
RTX.IgG2	IgG2
RTX.SEFL1.1^b	IgG1 N297G
RTX.SEFL2.0^b	IgG1 L242C,N297G,K334C
mAbW.IgG1	IgG1
mAbW.IgG2	IgG2
mAbW.SEFL1.1^b	IgG1 N297G
mAbW.SEFL2.0^b	IgG1 L242C,N297G,K334C
mAbW.SEFL2.1^b	IgG1 A287C,N297G,L306C
mAbW.SEFL2.2^b	IgG1 R292C,N297G,V302C

^a mAbX is referred to as AMG X in Ref. 9.

^b SEFL mAb are described in Jacobsen et al. (22).

^c mAbY.IgG2 is referred to as mAbY.1 in Ref. 10.