FIGURE 10.

Fgf16 overexpression results in intestinal abnormalities. A–F, histopathological analysis of ileum collected from EV mice (A, C, and E) and FGF16 mice (B, D, and F). A and B, Masson's trichrome staining identifies irregular collagen deposits within the lamina propria of FGF16 mice (yellow arrowheads). C and D, Alcian blue identifies increased deposition of acidic mucins within the lamina propria of FGF16 mice (black arrowheads). B and D, ileum from FGF16 mice also exhibit instances of crypt degeneration/abscesses (red arrowheads). E and F, no overt difference in periodic acid-Schiff staining was observed in ileum tissue from EV mice versus FGF16 mice. Images are representative of n = 8 animals/cohort.