Table 1.
Selected Physical Properties of Compounds Studieda
| molar mass (g/mol) |
Ki (nM) |
95% CI of Ki (nM) |
HPLC (RP) retention time (min) |
|
|---|---|---|---|---|
| 1 | 1284.4 | 0.70 | 0.42–1.16 | 19.2–19.8b |
| Ga-1 | 1352.5 | 0.33 | 0.17–0.66 | 26.8–31.7b |
| 2 | 1054.2 | 0.81 | 0.35–1.89 | 23.9–24.9c |
| Ga-2 | 1120.9 | 0.38 | 2.26–6.28 | 20.8–22.5c |
| DKFZ- PSMA-11 |
947.0 | 0.03 | 0.016–0.06 | 34.5–40.0c |
| Ga-DKFZ- PSMA-11 |
1013.7 | N.A. | N.A. | 14.5–20.0c |
| ZJ43 | 304.3 | 0.31 | 0.20–0.48 | N.A. |
a
Compounds 1 and 2 are the unlabeled compounds containing DOTA-monoamide and NOTA-Bn-SCN chelating agents, respectively.
b
Isocratic solution of 80% A and 20% B.
c
Isocratic solution of 85% water and 15% B. Flow rate was 1 mL/min for both methods.