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. Author manuscript; available in PMC: 2017 Feb 3.
Published in final edited form as: Bioconjug Chem. 2016 May 9;27(6):1447–1455. doi: 10.1021/acs.bioconjchem.5b00679

Table 2.

Tissue Biodistribution of 68Ga-1, 68Ga-2, and 68Ga-DKFZ-PSMA-11 in Mice Bearing PSMA+ PC3 PIP and PSMA-PC3 Flu Tumors (n = 4)a

68Ga-1
 68Ga-2
 68Ga-DKFZ-PSMA-11
tissue 1 h 2 h 3 h 1 h 2 h 3 h 1 h 2 h 3 h
blood 0.5 ± 0.1 0.3 ± 0.0 0.2 ± 0.0 0.4 ± 0.2 0.1 ± 0.0 0.1 ± 0.0 0.8 ± 0.2 0.4 ± 0.1 0.3 ± 0.1
heart 0.2 ± 0.0 0.1 ± 0.0 0.1 ± 0.0 0.2 ± 0.1 0.0 ± 0.0 0.0 ± 0.0 0.4 ± 0.2 0.3 ± 0.1 0.2 ± 0.0
lung 0.4 ± 0.0 0.2 ± 0.0 0.1 ± 0.0 1.0 ± 0.2 0.3 ± 0.0 0.2 ± 0.1 2.2 ± 0.5 2.1 ± 0.7 1.3 ± 0.2
liver 0.2 ± 0.0 0.2 ± 0.0 0.1 ± 0.0 0.5 ± 0.2 0.2 ± 0.0 0.2 ± 0.0 0.8 ± 0.2 0.3 ± 0.1 0.4 ± 0.2
spleen 1.0 ± 0.3 0.4 ± 0.0 0.4 ± 0.2 4.9 ± 0.7 0.8 ± 0.2 0.7 ± 0.1 12.4 ± 3.8 8.9 ± 1.5 7.2 ± 2.3
kidney 26.5 ± 6.9 11.9 ± 1.0 12.1 ± 5.6 106 ± 23 34.7 ± 5.7 12.7 ± 4.9 133 ± 21 89 ± 20 120 ± 16
muscle 0.1 ± 0.1 0.0 ± 0.0 0.0 ± 0.0 0.1 ± 0.0 0.0 ± 0.0 0.0 ± 0.0 0.3 ± 0.1 0.2 ± 0.1 0.1 ± 0.0
small intestine 0.2 ± 0.0 0.1 ± 0.0 0.1 ± 0.0 0.2 ± 0.1 0.0 ± 0.0 0.1 ± 0.0 0.4 ± 0.1 0.2 ± 0.1 0.2 ± 0.1
salivary gland 0.3 ± 0.0 0.2 ± 0.0 0.1 ± 0.0 0.2 ± 0.1 0.2 ± 0.1 0.1 ± 0.0 1.4 ± 0.3 1.0 ± 0.2 0.9 ± 0.1
PSMA+ PC3 PIP 19.5 ± 1.8 24.8 ± 1.1 19.5 ± 5.1 42.2 ± 6.7 21.7 ± 3.7 17.4 ± 5.6 26.0 ± 9.7 21.1 ± 1.2 26.9 ± 5.6
PSMA− PC3 flu 0.2 ± 0.0 0.2 ± 0.0 0.2 ± 0.0 0.4 ± 0.1 0.10 ± 0.0 0.1 ± 0.0 0.6 ± 0.1 0.4 ± 0.2 0.3 ± 0.1
PIP:flu 84 ± 4 149 ± 16 122 ± 31 110 ± 22 232 ± 26 182 ± 15 47 ± 8 58 ± 27 111 ± 21
PIP:kidney 0.8 ± 0.3 2.1 ± 0.1 1.8 ± 0.6 0.4 ± 0.1 0.7 ± 0.1 1.6 ± 0.1 0.2 ± 0.1 0.2 ± 0.0 0.2 ± 0.0
PIP:blood 59 ± 25 101 ± 10 236 ± 24 120 ± 29 321 ± 79 207 ± 33 36 ± 13 52 ± 11 80 ± 10
PIP:salivary gland 77 ± 3 157 ± 3 173 ± 27 188 ± 35 212 ± 3 222 ± 35 18.6 ± 9.0 21 ± 3 31 ± 5
a

Values are expressed as mean ± SD.