TABLE 2.
Comparison of lung mRNA expression on day 21 postinfection in mice infected with M. tuberculosis ΔfbpA or H37Rv
| Cytokine or agent | Avg change in lung mRNA expression (n-fold) ± SD for:
|
P value (n = 8)a | |
|---|---|---|---|
| ΔfbpA | Wild-type H37Rv | ||
| TNF-α | 155.4 ± 40.1 | 84.3 ± 84.0 | 0.0486 |
| IFN-γ | 76.8 ± 9.7 | 42.3 ± 40.2 | 0.0333 |
| IL-1β | 107.8 ± 26.3 | 59.7 ± 57.6 | 0.0496 |
| iNOS | 157.5 ± 24.8 | 87.0 ± 82.8 | 0.0369 |
| IL-6 | 165.2 ± 22.3 | 88.0 ± 80.0 | 0.0198 |
| IL-10 | 52.5 ± 0.5 | 27.5 ± 27.0 | 0.0204 |
| IL-12 | 33.5 ± 18.4 | 17.9 ± 17.0 | 0.1000 |
| IL-2 | 4.9 ± 2.1 | 2.6 ± 2.0 | 0.0416 |
| IL-4 | 1.9 ± 1.9 | 2.1 ± 2.0 | 0.8405 |
| IL-5 | 4.1 ± 3.9 | 2.4 ± 2.0 | 0.2911 |
a
P values of <0.05 were considered significant (t test).