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. 2004 Dec;72(12):6773–6779. doi: 10.1128/IAI.72.12.6773-6779.2004

FIG. 4.

FIG. 4.

H. pylori downregulates the CXCR1 and CXCR2 receptors on neutrophils, as shown by confocal microscopy. Purified human neutrophils showed strong CXCR1 and CXCR2 expression at the cell membrane and in the cytoplasm after 0.5 h of incubation in RPMI medium. Incubation with a cag+ and a cag deletion H. pylori strain for 0.5 h resulted in a strong reduction of the fluorescence signals, with complete loss of the signals at the cell membrane and only some CXCR1 and CXCR2 signal in the cytoplasm. Fluorescence microscopy is shown in the lower part of the figure, and transmission light microscopy of the same cells is shown in the upper part of the figure.