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Downmodulation of the CXCR1 receptor on neutrophils may also occur during H. pylori infection in the human stomach. Neutrophils in the lamina propria expressed the CXCR1 receptor, whereas neutrophils infiltrating gastric epithelium or localized in the foveolar lumen (arrows), where they are in closer contact with H. pylori, lacked CXCR1 expression.
