TABLE 5.
IFN-γ in sera of mice infected with F. tularensis LVSa
| Mouse strain | IFN-γ concn in serum (pg/ml)
|
||||
|---|---|---|---|---|---|
| Day 0b | Day 3c | Day 6c | Day 9c | Day 10c | |
| p47phox+/+ | <30 | 1,070 ± 390 | 4,340 ± 2,590 | 220 ± 25 | 280 ± 15 |
| p47phox−/− | <30 | 2,088 ± 418d | 6,190 ± 2,510 | 3,600 ± 640 C | 2,010 ± 75 B |
| iNOS+/+ | <30 | 1,530 ± 620 | 3,243 ± 1,641 | NDe | <30 |
| iNOS−/− | <30 | 2,790 ± 1,500 | 12,080 ± 575 A | 6,490 ± 1,220 | 2,020 ± 710 A |
| iNOS+/+ 129 | <30 | 1,190 ± 440 | 1,650 ± 240 | ND | 220 ± 120 |
| Leaky iNOS−/− | <30 | 1,530 ± 525 | 4,000 B | ND | 150 ± 45 |
a
The intradermal inoculum was 5 × 104 CFU of F. tularensis LVS per mouse.
b
IFN-γ serum levels before inoculation of F. tularensis LVS.
c
Means ± standard errors of the means for three samples.
d
Significance is indicated as follows: A, P < 0.05 compared to wild-type mice; B, P < 0.01 compared to wild-type mice; C, P < 0.001 compared to wild-type mice.
e
ND, not determined.