TABLE 3.
Comparative recognition of synthetic and natural PRP oligosaccharide conjugatesa
| Rabbit no. | Vaccine | Polysaccharide | sPRP-HSA | HbO-HA | sPRP-BSA |
|---|---|---|---|---|---|
| 1 | PRP-CRM197 | Oligosaccharide | 1.98 | 2.14 | |
| 2 | PRP-CRM197 | Oligosaccharide | 3.51 | 3.66 | |
| 3 | PRP-CRM197 | Oligosacchide | 2.93 | 3.00 | |
| 4 | PRP-TT | Polysaccharide | 2.63 | 2.73 | |
| 5 | PRP-TT | Polysaccharide | 1.54 | 1.13 | |
| 6 | PRP-TT | Polysaccharide | 3.25 | 3.10 | |
| 7 | PRP-TT | Polysaccharide | 2.08 | 1.73 | |
| 8 | PRP-TT | Polysaccharide | 2.72 | 2.60 | |
| 11 | PRP-CRM197 | Oligosacchide | 3.76 | 3.73 | |
| 12 | PRP-CRM197 | Oligosacchide | 3.23 | 3.23 | |
| 13 | PRP-CRM197 | Oligosacchide | 2.91 | 2.94 | |
| 14 | PRP-TT | Polysaccharide | 2.62 | 2.46 | |
| 15 | PRP-TT | Polysaccharide | 2.27 | 2.42 | |
| 16 | PRP-TT | Polysaccharide | 2.72 | 2.83 | |
| 17 | PRP-TT | Polysaccharide | 3.29 | 3.37 | |
| 18 | PRP-TT | Polysaccharide | 2.76 | 2.84 |
a
Rabbits were immunized with PRP-TT or PRP-CRM197. For rabbits 1 to 8, sPRP- and PRP-HSA conjugates were used as coating reagent; for rabbits 11 to 18, the coating antigen used was sPRP with two different protein carriers, HSA and BSA. Values are for individual sera.