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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Transl Stroke Res. 2016 Apr 28;7(3):228–238. doi: 10.1007/s12975-016-0468-4

Fig. 1.

Fig. 1

Effect of early post-ischemic reperfusion and tissue plasminogen activator (tPA) on myogenic reactivity and tone of middle cerebral arteries (MCAs) and parenchymal arterioles (PAs). Early post-ischemic reperfusion decreased myogenic tone in MCAs but not in PAs. (a) Inner diameter of MCAs and PAs in response to pressure. MCAs and PAs showed myogenic reactivity to increased pressure in all groups. The active diameters of MCAs were significantly larger after middle cerebral artery occlusion (MCAO). (b) Percent tone of MCAs at 75 mmHg and PAs at 40 mmHg. MCAs had decreased tone after MCAO independent on treatment with vehicle (Vh) or tPA. No effect of MCAO and tPA on tone was seen in PAs. *P<0.05, Two-way ANOVA main effect of MCAO. #P<0.05, unpaired t test vs MCA: Sham Vh