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. 2017 Feb 3;37(1):BSR20160479. doi: 10.1042/BSR20160479

Figure 4. TSC1 knockdown enhances hypoxia-mediated lymphocyte death via mTORC1 activation.

Figure 4

(A) MTT assay showed that hypoxia reduces cell viability in hypoxia lymphocytes, whereas TSC1 knockdown enhances the cell death. Rapamycin treatment may rescue TSC1 knockdown-mediated cell death in hypoxia lymphocytes. (B–C) Western blots and quantifications showed that hypoxia induces cleaved caspase-3 protein levels and TSC1 knockdown enhances it. Rapamycin treatment may rescue TSC1 knockdown-induced cleaved caspase-3 in hypoxia lymphocytes. Results are averages of three independent experiments. Data represent mean ± S.E.M.; **P<0.01.