TABLE 1.
Reduced internalization of GFP-BCG by TLR2-TLR4-deficient macrophagesa
| Mouse genotype | Infection index | Uptake inhibition (%) | P |
|---|---|---|---|
| TLR2+/+ TLR4+/+ | 4.91 ± 1.67 | 0 | |
| TLR2+/+ TLR4−/− | 4.46 ± 2.15 | 9.3 | NS |
| TLR2−/− TLR4+/+ | 4.87 ± 2.70 | 1.0 | NS |
| TLR2−/− TLR4−/− | 3.13 ± 1.29 | 36.4 | 0.01-0.02 |
a
Results are expressed as the infection index (percentage of cells containing one or two isolated bacilli) ± the standard deviation determined from 10 different observation fields for 1 slide (12 slides) that represents 5,200 macrophages observed per genotype. The percentage of inhibition of uptake is indicated. P = significance (C1 test of Fisher-Yates-Terry). P values of < 0.05 were considered to be statistically significant.