Table 2.
BCR-ABL genetic testing descriptive, bivariate, and multi-variable analysis
| Variables | CML cases with documented BCR-ABL gene testing (excluding State A) N=393 |
Bivariate Analysis (excluding State A) |
Multivariable Analysis (excluding State A) |
|---|---|---|---|
| n= (%*) | OR (95% CI) | OR (95% CI) | |
| Age at Diagnosis | |||
| <50 | 116 (84.7%) | ref | |
| 50–59 | 62 (80.5%) | 0.748 (0.360–1.554) | |
| 60–69 | 56 (75.7%) | 0.563 (0.278–1.141) | |
| 70–79 | 71 (67.6%) | 0.378 (0.204–0.702) | |
| Age as Continuous | 0.971 (0.953–0.990) | ||
| Sex | |||
| Male | 161 (78.9%) | ref | ref |
| Female | 144 (76.6%) | 0.874 (0.543–1.408) | 0.873 (0.496–1.539 |
| Race/Ethnicity | |||
| Non-Hispanic White | 201 (75.6%) | ref | ref |
| Non-Hispanic Black | 47 (81.0%) | 1.382 (0.677–2.820) | 1.054 (0.443–2.510) |
| Hispanic | 44 (81.5%) | 1.423 (0.678–2.986) | 1.296 (0.516–3.255) |
| Non-Hispanic Other | 7 (77.8%) | 1.132 (0.229–5.585) | 1.456 (0.214–9.900) |
| Missing | 6 | ||
| Health Insurance | |||
| Private | 148 (82.2%) | ref | ref |
| Insurance NOS | 15 (71.4%) | 0.540 (0.195–1.500) | 0.310 (0.096–1.004) |
| Medicaid and other public insurance |
51 (78.5%) | 0.788 (0.390–1.593) | 0.587 (0.259–1.332) |
| Medicare | 59 (72.8%) | 0.580 (0.312–1.079) | 0.682 (0.315–1.481) |
| No Insurance | 21 (80.8%) | 0.908 (0.319–2.589) | 0.566 (0.171–1.876) |
| Missing | 20 | ||
| Census Tract Residence** | |||
| 100% Urban | 162 (76.8%) | ref | ref |
| 100% Rural | 25 (78.1%) | 1.080 (0.441–2.649) | 1.253 (0.409–3.838) |
| Mixed | 114 (78.1%) | 1.078 (0.650–1.787) | 1.832 (0.904–3.713) |
| Missing | 4 | ||
| Census Track Poverty*** | |||
| Poverty <20% | 251 (75.8%) | ref | ref |
| Poverty ≥ 20% | 50 (86.2%) | 1.992 (0.906–4.379) | 1.937 (0.788–4.758) |
| Missing | 4 | ||
| State of Residence | |||
| State A [69 (23.6%) BCR-ABL tested] |
|||
| State B | 81 (67.5%) | ref | ref |
| State C | 70 (95.9%) |
11.231 (3.326– 37.925) |
20.944 (4.694–93.510) |
| State D | 53 (82.8%) | 2.320 (1.092–4.928) | 3.189 (1.163–8.742) |
| State E | 46 (82.1%) | 2.215 (1.012–4.848) | 3.215 (1.180–8.760) |
| State F | 15 (51.7%) | 0.516 (0.227–1.174) | 0.644 (0.237–1.749) |
| State G | 17 (85.0%) | 2.728 (0.754–9.867) | 3.454 (0.885–13.485) |
| State H | 11 (73.3%) | 1.324 (0.396–4.425) | 1.539 (0.368–6.433) |
| State I | 9 (90.0%) | 4.333 (0.530–35.422) | >999.999 (<0.001–>999.999) |
| State J | 3 (50.0%) | 0.481 (0.093–2.495) | 0.088 (0.006–1.393) |
*
% of category tested for BCR-ABL gene
**
Census tracts urbanization defined as urban if 100% of addresses in the census tract are located in an urban setting, 100% rural if 100% of addresses in the census tract are located in an urban setting, or mixed
***
Poverty- patient categorized into two categories based on census tract of residence (i.e. where less than 20% of the families in the census tract had income below the poverty line in the last 12 months OR 20% or more of households in patient census tract had income below the poverty line in the last 12 months)
Note: Bolding indicates significant finding