Table 4.
Replication analysis in the TwinsUK and Exeter cohorts
| CpG Island & Shores | Probe |
ALSPAC |
TwinsUK |
Exeter |
|||
|---|---|---|---|---|---|---|---|
| nVars | P-value | nVars | P-value | nVars | P-value | ||
| chr21:45,728,220–45,732,444 | cg21069494 | 6 | 6.24x10−24 | 6 | 8.13x10−5 | 0 | N/A |
| chr8:144,715,866–144,720,798 | cg16316162 | 3 | 4.02x10−23 | 3 | 1.14x10−6 | 2 | 4.67x10−18 |
| chr11:66,492,937–66,498,387 | cg24851651 | 6 | 2.68x10−21 | 6 | 0.03 | 2 | 2.14x10−4 |
| chr2:75,785,717–75,790,312 | cg26175789 | 8 | 6.73x10−21 | 8 | 1.42x10−3 | 5 | 7.57x10−16 |
| chr12:120,753,346–120,757,672 | cg06379361 | 5 | 1.21x10−20 | 5 | 8.23x10−3 | 2 | 1.63x10−7 |
| chr7:100,873,555–100,878,212 | cg01299997 | 7 | 1.26x10−20 | 7 | 4.85x10−5 | 3 | 8.45x10−3 |
| chr3:53,076,956–53,083,101 | cg04865290 | 10 | 2.03x10−20 | 10 | 9.23x10−6 | 3 | 5.44x10−18 |
| chr2:196,519,555–196,524,950 | cg19655195 | 8 | 2.23x10−20 | 8 | 4.55x10−3 | 3 | 1.85x10−7 |
| chr1:1,287,707–1,293,126 | cg17132079 | 3 | 1.11x10−19 | 3 | 1.01x10−3 | 0 | N/A |
| chr11:64,407,877–64,413,253 | cg19395706 | 4 | 1.43x10−19 | 4 | 7.61x10−7 | 0 | N/A |
nVars = number of variants analysed. This varied depending on imputation quality for each cohort. P-value according to SKAT.