Table 3. Association between IL1B haplotypes and AP or CRC risk among Colombians stratified by region of origin.

IL1B gene haplotypes by region	N°	Total (n = 791) Frequency	Controls	Adenomatous Polyps (AP)				Colorectal Cancer (CRC)
			Frequency	Frequency	OR	[95% CI]	p value	Frequency	OR	[95% CI]	p value
Andean
		(n = 367)	(n = 163)	(n = 79)				(n = 125)
CGCT	1	0.125	0.138	0.127	0.94	[0.51–1.73]	0.83	0.108	0.70	[0.40–1.22]	0.21
CGTC	3	0.067	0.067	0.070	1.31	[0.56–3.06]	0.53	0.064	0.91	[0.45–1.86]	0.80
CCTC	4	0.459	0.463	0.405	1	ref	ref	0.488	1	ref	ref
TGCT	5	0.346	0.328	0.399	1.52	[0.96–2.40]	0.08	0.336	0.98	[0.68–1.42]	0.92
Coastal
		(n = 424)	(n = 180)	(n = 84)				(n = 160)
CGCT	1	0.125	0.142	0.125	0.98	[0.54–1.79]	0.95	0.106	0.93	[0.56–1.55]	0.79
CGCC	2	0.022	0.028	0.018	0.93	[0.24–3.62]	0.91	0.019	0.81	[0.29–2.28]	0.69
CGTC	3	0.173	0.139	0.143	1.23	[0.65–2.32]	0.52	0.228	2.06	[1.31–3.25]	<0.01
CCTC	4	0.366	0.392	0.345	1	ref	ref	0.347	1	ref	ref
TGCT	5	0.312	0.297	0.369	1.52	[0.93–2.49]	0.10	0.300	1.14	[0.77–1.69]	0.52

P values for the adjusted GLM analyses to evaluate the effect of IL1B haplotypes on AP and CRC risk stratified by region of origin.

OR shows the effect of IL1B haplotypes on AP and CRC risk adjusted for sex, age and educational level.