TABLE 1.
Protection of gerbils from amebic liver abscess by oral vacccination with recombinant Y. enterocolitica WA irp1 expressing various YopE-lectin fusion proteins
| Vaccine group | No. of gerbils with liver abscess/no. of gerbils challenged | % of gerbils protecteda | Size of liver abscess in nonprotected animals (% of control)a |
|---|---|---|---|
| WA irp1 (control) | 46/48 | 4.2 | |
| YopE-T-170EC | 6/10 | 40.0 | 68.6 |
| YopE-T-170CP | 3/10 | 70.0 A | 45.3 C |
| YopE-S-170CRc | 13/14 | 7.1 | 52.9 |
| YopE-T-170CRc | 8/11 | 27.3 | 82.4 |
| YopE-S-170CR2 | 10/15 | 33.3 | 58.7 |
| YopE-T-170CR2 | 5/14 | 64.3 B | 34.8 D |
a
Significant differences from WA irp1 control, as determined by Fisher's exact test, are indicated by A, P < 0.002; B, P < 0.001; C, P < 0.05; and D, P < 0.005.