Table 1.
Samples included in the study at age 1 year and at age 2 years by diarrhoeal disease definition and study phase
| Age 1 year |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Diarrhoea (D1Y) |
Doctor diagnosis of diarrhoea (DD1Y) |
||||||||||
| Cohort | Assessment (period in months)a | N total | N cases | % cases | Cohort | Assessment (period in months)a | N total | N cases | % cases | ||
| Discovery | ALSPAC (Disc)d | Questionnaire (6–18) | 3363 | 2001 | 59.5 | ALSPAC (Disc)d | Questionnaire (6–18) | 3363 | 893 | 26.6 | |
| Generation R | Questionnaire (6–12)c | 2033 | 469 | 23.1 | Generation R | Questionnaire (6–12)c | 2033 | 179 | 8.8 | ||
| INMA_SAB | Questionnaire (6–14) | 362 | 223 | 61.6 | COPSAC2000 | Doctor interview (6–12) | 345 | 81 | 23.5 | ||
| LISAplus | Questionnaire (6–12) | 662 | 186 | 28.1 | |||||||
| TOTAL | 5758 | 2693 | 46.8 | TOTAL | 6403 | 1339 | 21.8 | ||||
| Replication | ALSPAC (Repl) | Questionnaire (6–18) | 3361 | 2047 | 60.9 | ALSPAC (Repl) | Questionnaire (6–18) | 3361 | 871 | 25.9 | |
| MoBa | Questionnaire (6–18)c | 407 | 255 | 62.6 | COPSAC2010 | Doctor interview (6–12) | 547 | 244 | 44.6 | ||
| INMA_VAL | Questionnaire (0–12) | 334 | 149 | 44.6 | |||||||
| CHOPb | Medical records (6–18) | 3223 | 147 | 4.6 | |||||||
| TOTAL | 3768 | 2302 | 61.1 | TOTAL | 7465 | 1411 | 18.9 | ||||
| Age 2 years |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Diarrhoea (D2Y) |
Doctor diagnosis of diarrhoea (DD2Y) |
||||||||||
| Cohort | Assessment (period in months)a | N total | N cases | % cases | Cohort | Assessment (period in months)a | N total | N cases | % cases | ||
| Discovery | ALSPAC (Disc)d | Questionnaire (18–30) | 3189 | 1746 | 54.8 | ALSPAC (Disc) | Questionnaire (18–30) | 3189 | 514 | 16.1 | |
| Generation R | Questionnaire (18–24)c | 2058 | 943 | 45.8 | Generation R | Questionnaire (18–24)c | 2058 | 190 | 9.2 | ||
| INMA_SAB | Questionnaire (12–24) | 361 | 166 | 46 | COPSAC2000 | Doctor interview (18–24) | 319 | 86 | 27 | ||
| LISAplus | Questionnaire (18–24) | 667 | 200 | 30 | |||||||
| TOTAL | 5608 | 2855 | 50.9 | TOTAL | 6233 | 990 | 20.6 | ||||
| Replication | ALSPAC (Repl)d | Questionnaire (18–30) | 3187 | 1759 | 55.2 | ALSPAC (Repl) | Questionnaire (18–30) | 3187 | 485 | 15.2 | |
| INMA_VAL | Questionnaire (12–14) | 329 | 213 | 64.7 | COPSAC2010 | Doctor interview (18–24) | 518 | 271 | 52.3 | ||
| GINIplusd | Questionnaire (12–24) | 794 | 328 | 41.3 | |||||||
| CHOPb | Medical records (18–30) | 3223 | 190 | 5.9 | |||||||
| Total | 3516 | 1972 | 56.1 | Total | 7722 | 1274 | 16.5 | ||||
a
Period referred in the questionnaire, medical record or doctor interview.
b
Only children not vaccinated against Rotavirus were included.
c
It refers specifically to gastric flu or gastroenteritis.
d
Statistically significant differences in the proportions of diarrhoeal disease among males and females (P-value < 0.05) [ALSPAC-D1Y-Discovery: 61.2% males versus 57.7% females; ALSPAC–DD1Y-Discovery: 29.2% versus 23.8%; ALSPAC-D2Y-Discovery: 56.6% versus 52.8%; ASLPAC-D2Y-Replication: 58.5% versus 51.7%; and GINIplus-DD2Y-Replication: 46.7% versus 36.0%].