Figure 6.

Modelling the sequence specificity of RNA binding factors is challenging but improves with higher orders. (A) Increase of prediction performance of second- versus zeroth-order BaMMs for binding sites of 25 mRNP biogenesis factors from S. cerevisiae measured by PAR-CLIP. Dashed line: mean fold increase. (B) Left: higher-order BaMMs lead to sizeable gains in precision and recall for predicting Hrb1 binding sites. Right: sequence logos for order 0 and 1 of second-order BaMM (central crosslinked U was removed from the zeroth-order logo). (C and D) Effect of BaMMs model order on prediction performance for Nab3 (C) and Yra1 (D).