Table 5.
DTX pharmacokinetic parameters in mouse heart after IV injection of different drug formulations (n=4)
| DTX formulation
| ||||
|---|---|---|---|---|
| Tissue | PK parameter | DTX solution | PLGA NPs | PLGA–PEG NPs |
| Heart | T1/2 (h)* | 21.74±3.88 | 11.34±2.25 | 14.00±4.76 |
| Cl (mL/h) | 1.12±0.47 | 1.28±0.58 | 2.14±1.00 | |
| AUC (ng/mL h) | 100,652±39,953 | 90,445±37,835 | 56,297±27,440 | |
| MRT (h) | 28.08±8.10 | 17.36±2.28 | 20.71±8.73 | |
Note:
*
Statistically significant difference between treatment groups.
Abbreviations: T1/2, half-life; AUC, area under the curve; Cl, clearance; IV, intravenous; MRT, mean residence time; PEG, poly(ethylene glycol); PLGA, poly(lactide-co-glycolide); DTX, docetaxel; NP, nanoparticle; PK, pharmacokinetic.