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. 2017 Feb 3;12(2):e0171757. doi: 10.1371/journal.pone.0171757

Fig 3. Antigen-induced arthritis severity is potently reduced by combinatorial blockade of IL-6 and IL-21 signaling pathways.

Fig 3

Joint swelling of WT, IL-6-/-, IL-21R-/-, and IL-6-/- x IL-21R-/- mice at day 1 (A), day 2 (B), and day 4 (C) after arthritis induction, depicted as ratio between right and left knee joint, measured by 99mTechnetium pertechnetate uptake in the joint (n = 6/group). Histologically scored inflammation, bone erosion (both H&E staining, scale bar 500 μM), and cartilage proteoglycan depletion (SafO staining, scale bar 200 μM) (D; n = 10/group). *p<0.05, **p<0.01, ***p<0.001 versus WT; #p<0.05, ###p<0.001 versus IL-6-/-; ^p<0.05 versus IL-21R-/-; A+B One-way ANOVA, C+D Kruskal-Wallis.