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. 2017 Feb 3;12(2):e0171356. doi: 10.1371/journal.pone.0171356

Fig 4. Dasatinib, Src family inhibitor, overcomes HER2-resistance.

Fig 4

(A) MTS assay evaluating the effect of trastuzumab or lapatinib alone, dasatinib alone or the combination on BT-474, BT-474-R and BT-474-RL2. Data are shown as means + SE. The assay was repeated three times. (B) Clonogenic assay evaluating the effect of long-term exposure to trastuzumab alone, dasatinib alone or the combination of them on BT-474-R and BT-474-RL2. Data are shown as means + SE. The assay was repeated three times. (C) Soft agar colony formation assay in BT-474-R and BT-474-RL2. Data are shown as means + SE. The assay was repeated three times. (D) phosphorylation status of HER2 and Akt upon treatment with trastuzumab alone, dasatinib alone or the combination of them for 1 hour in BT-474, BT-474-R and BT-474-RL2.