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. 2017 Feb 3;12(2):e0171276. doi: 10.1371/journal.pone.0171276

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© 2017 Lama et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — Effects of SW and RAL treatment on histological features of vertebrae (V), femural metaphyseal bone (F) and contralateral femurs (Fct) of SHAM (A,F,K), OVX (B,G,L), OVX+SW (C,H,M), OVX+RAL (D,I,N) and OVX+SW+RAL (E,J,O) groups (panel A). Bone sections were stained with H&E to visualize trabecular thickness and organization, and adipose tissue infiltration in bone marrow. Effects of SW and RAL treatments on bone markers in serum: ALP (panel B), iPTH (panel C) and OPG/RANKL ratio (panel D). Values are expressed as means ± SEM (n = 6); **P <0.01 and ***P <0.001 compared with SHAM; #P <0.05, ##P <0.01 and ###P <0.001 compared with OVX.