Table 1. Summary of data extracted from 12 studies included in the meta-analysis.

Study	Year of publication	Journal	Types of diseases	Population studied	Patient (total)	Diagnosis criteria of disease	Rate of SETBP1 mutation case	Method to distinguish mutations	SETBP1 mutations
A Pardanani [14]	2013	Leukemia	CNL	USA	35	WHO classification	17%	PCR and Sanger sequencing	D868N D870D G827R G870S
Daichi Inoue [15]	2015	Leukemia	MDS	Taiwan	386	WHO classification	9%	PCR and Sanger sequencing	D868N E858K G870S S867R
F Damm [6]	2013	Leukemia	CMML	France	195	WHO classification	6%	PCR and Sanger sequencing	D868N G870S G870D E858K D868H S869G S869R I871S D908N
F Thol [12]	2013	Leukemia	AML and MDS	German	326	WHO classification	2%	PCR and Sanger sequencing	D868N G870S S854A S869N
Hideki Makishima [5]	2013	Nat Genet	MM	Japan	727	WHO classification	-	PCR and Sanger sequencing	D868N G870S I871T D868T D880N S869N D880E
Hou [10]	2014	American Journal of Hematology	MDS	Taiwan	430	WHO classification	3%	PCR and Sanger sequencing	D868N G870S E858K S867R I871T
M Meggendorfer [16]	2013	Leukemia	CMML and aCML	Italy	227	WHO classification	12%	PCR and Sanger sequencing	G870S I871T G870D
Michelle A. Elliott [7]	2015	American Journal of Hematology	CNL	USA	13	WHO classification	31%	-	G870D D868N G872R
Mrinal M. Patnaik [17]	2015	American Journal of Hematology	CMML	USA	36	WHO classification	3%	-	-
RR Laborde [11]	2015	Leukemia	CMML	USA	179	-	4%	PCR and Sanger sequencing	D868N D868Y G870S I871T
Vera Adema [18]	2015	British Journal of Haematology	MDS	Barcelona	25	WHO classification	50%	PCR and Sanger sequencing	-
Cui [19]	2014	Chinese Journal of Hematology	CNL	China	8	WHO classification	50%	PCR and Sanger sequencing	D847N D868N G870S I871T

WHO: World Health Organization

MM: Myeloid Malignancies

CNL: Chronic neutrophilic leukemia

aCML: Atypical chronic myeloid leukemia

MDS: Myelodysplastic syndromes

CMML: Chronic myelomonocytic leukemia