FIG. 5.

Time course of PGE₂ and PGI₂ production in macrophages infected with Salmonella. Macrophages were infected with wild-type (WT), spiC, or purB Salmonella strains. At the time points indicated, supernatants were harvested and tested for PGE₂ (A) and PGF_1α (B) content by enzyme-linked immunosorbent assay. The inset shows the results at 20 h postinfection. The data are the means and SD of three independent experiments. ∗, P < 0.001 (significantly different from macrophages infected with wild-type Salmonella). UI, uninfected.