Table 2. Inhibitory activity (IC50, μM) against MAO-A and -B and selectivity index for LSD1.
LSD1 | MAO-A | MAO-B | Selectivity index | |
---|---|---|---|---|
1 | 0.0098 | 17.5 | 34.2 | >1,700 |
2 | 0.077 | 120 | 480 | >1,500 |
3 | 0.035 | 7.3 | 16.3 | >208 |
7 | 0.91 | 0.17 | 0.35 | <0.38 |
8 | 5.3 | 0.42 | 3.1 | <0.58 |
10 | 0.064 | 18.1 | 23.1 | >280 |
11 | 0.62 | 0.26 | 0.51 | <0.82 |
16 | 0.062 | 2.4 | 1.8 | >29 |
26 | 0.74 | 0.30 | 0.40 | <0.54 |
31 | 5.8 | 40.7 | 87.0 | >7 |
32 | 0.67 | 97.5 | 370 | >145 |