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(A) In ddc1Δ and dpb2-103 cells replication checkpoint activation is partially impared whereas in ddc1Δ dpb2-103 cells is abolished. (B) The two branches i. e. DDR (Dun1/Crt1) and CC (Nrm1/MBF) are activated in wild type cells and inactive in rad53 or mec1 checkpoint mutants. In dpb2-103 cells the Nrm1/MBF branch is inactive.
