Fig 6. Comparison of simulated channel blockade with experimental findings.

Simulated blockade of the sodium currents via TTX (B) and of IK₁ current via barium chloride (D) qualitatively replicates the effects of experimental blockade (A: experimental TTX; C: experimental BaCl₂). Note that there is a sigmoidal relationship between drug dose and degree of block, and that the x-axis of panels B and D has been inverse-sigmoidally transformed to allow for direct comparison of simulated response and experimental results. Panels A and C from [7], used with permission.