Fig 7. Conduction slowing due to increased extracellular potassium.

An increase in extracellular potassium concentration in experimental Ex293 monolayers leads to conduction slowing, and conduction failure for concentrations greater than 7.4 mM (closed circles). The model shows similar behavior, but conduction failure occurs at a lower concentration (open diamonds). When the model is modified to reflect non-Nernstian changes in potassium reversal potential, conduction slowing more closely replicates experimental observations (open squares).