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. 2016 Jan 29;95(4):e2614. doi: 10.1097/MD.0000000000002614

FIGURE 3.

FIGURE 3

The dynamic changes in HBV DNA levels and resistant variants of the RT domains during ETV treatment of patient 3. (A) The serum HBV DNA level declined gradually and was undetectable by the 5th year of ETV treatment. (B) At baseline, the virus only harbored an rtA181T substitution (1.2%) and had low fluctuations during the follow-up period. Resistant variants (rtM204I/rtV173 M/A) increased to 9.23%/1.87% in 24 weeks and declined to <1% at 1 year. Two variants (rtI187L/rtV191I) rose to a high level during the 4th year (84.43% /83.41%), and 2 other variants, namely, rtN248H and rtS256G, were maintained at a high level (>60%). ETV = entecavir, DNA = di-ribonucleic acid, HBV = hepatitis B virus, RT = reverse transcriptase.