FIGURE 4.

The dynamic changes in HBV DNA levels and resistant variants of the RT domains during ETV treatment of patient 4. (A) The serum HBV DNA level was undetectable after treatment for 5 years. (B) Resistance mutations displayed low levels of fluctuation (<7%), and nonresistant variants (rtN248H/rtS223A) rose to 12.88%/13.1% by 2 years. Additionally, rtS256G substitutions were maintained at a high level (>55%).ETV = entecavir, DNA = di-ribonucleic acid, HBV = hepatitis B virus, RT = reverse transcriptase.