FIGURE 1.

TP53 alteration is associated with significant shorter overall survival in the whole cohort while its prognostic value is attenuated in patients with MYC translocation. Kaplan–Meier plots showing (A) overall survival of all patients (N = 101) according toTP53 deletion/mutation; (B) overall survival of MYC negative patients (N = 48) according to TP53 deletion/mutation; and (C) overall survival of MYC positive patients (N = 53) according to TP53 deletion/mutation. The negative prognostic impact of TP53 alteration is reduced and loses significance in patients with a concurrent MYC translocation. P: P-value.