TABLE 1.
Group,b subject, or parameter | IgG titer to:
|
IgA titer to:
|
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Pertussis toxin
|
FHA
|
Pertactin
|
Pertussis toxin
|
FHA
|
Pertactin
|
|||||||
Prec | Postd | Pre | Post | Pre | Post | Pre | Post | Pre | Post | Pre | Post | |
Group A | ||||||||||||
32-60 | 3 | 17 | 4 | 25 | 4 | 15 | 3 | 3 | 4 | 5 | 12 | 19 |
26-47 | 3 | 33 | 22 | 124 | 17 | 222 | 3 | 3 | 13 | 133 | 8 | 199 |
6-40 | 3 | 39 | 4 | 264 | 14 | 114 | 3 | 3 | 4 | 5 | 4 | 7 |
18-54 | 3 | 98 | 4 | 1,744 | 10 | 291 | 3 | 3 | 4 | 26 | 4 | 14 |
16-52 | 3 | 30 | 4 | 352 | 4 | 92 | 3 | 9 | 4 | 89 | 5 | 38 |
14-50 | 3 | 112 | 4 | 336 | 8 | 319 | 3 | 3 | 4 | 22 | 4 | 38 |
27-48 | 3 | 37 | 15 | 154 | 6 | 917 | 3 | 3 | 13 | 35 | 4 | 68 |
19-72 | 3 | 72 | 7 | 287 | 26 | 423 | 3 | 3 | 4 | 34 | 15 | 351 |
GMTe | 3.0 | 45.7 | 6.3 | 228.6 | 9.1 | 183.0 | 3.0 | 3.4 | 5.4 | 25.9 | 6.1 | 43.5 |
95% CIf | 3.0g | 26.7-78.5 | 84.3-620 | 64.7-517 | 3.5-11.2 | 5.2-16.1 | 3.0 | 3.4-8.5 | 3.8-9.6 | 2.5-4.8 | 9.6-69.6 | 14.4-131 |
Group B | ||||||||||||
31-57 | 3 | 48 | 4 | 936 | 30 | 349 | 3 | 5 | 32 | 1,308 | 9 | 212 |
10-68 | 8 | 124 | 25 | 754 | 13 | 1,746 | 3 | 7 | 45 | 2,051 | 9 | 257 |
4-43 | 3 | 166 | 9 | 580 | 11 | 1,525 | 3 | 3 | 4 | 55 | 4 | 56 |
20-55 | 3 | 132 | 4 | 342 | 12 | 1,553 | 3 | 6 | 4 | 13 | 5 | 163 |
23-63 | 3 | 58 | 32 | 376 | 42 | 2,520 | 3 | 19 | 14 | 252 | 179 | 1,843 |
8-45 | 3 | 69 | 9 | 660 | 17 | 2,224 | 3 | 5 | 5 | 567 | 8 | 1,828 |
1-37 | 3 | 20 | 68 | 158 | 77 | 398 | 3 | 3 | 37 | 68 | 18 | 71 |
GMT | 3.5 | 72 | 13.2 | 475 | 22 | 1,182 | 3.0 | 5.6 | 12.9 | 211 | 12.3 | 275 |
95% CI | 2.4-4.9 | 37-142 | 4.9-36 | 272-832 | 11-44 | 559-2,500 | 3.0 | 3.2-10.0 | 4.7-35 | 38-1,160 | 3.8-40 | 75-101 |
Vaccine titers were significantly different for group A and group B, namely, preimmunization IgG titer to pertactin (P < 0.03), postimmunization IgG titer to pertactin (P < 0.005), IgA titer to FHA (P < 0.02), and IgA titer to pertactin (P < 0.03).
Group A is the group of subjects with unaltered bactericidal activity after immunization with pertussis vaccine. Group B is the group of subjects with altered bactericidal activity after immunization with pertussis vaccine.
Pre, preimmunization.
Post, postimmunization.
GMT, geometric mean titer.
95% CI, 95% confidence interval.
A value of 3.0 is shown when no variability was observed.