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. 2004 Dec;72(12):7346–7351. doi: 10.1128/IAI.72.12.7346-7351.2004

TABLE 1.

Pre- and postimmunization antibody titers sorted by bactericidal responsesa

Group,b subject, or parameter IgG titer to:
IgA titer to:
Pertussis toxin
FHA
Pertactin
Pertussis toxin
FHA
Pertactin
Prec Postd Pre Post Pre Post Pre Post Pre Post Pre Post
Group A
    32-60 3 17 4 25 4 15 3 3 4 5 12 19
    26-47 3 33 22 124 17 222 3 3 13 133 8 199
    6-40 3 39 4 264 14 114 3 3 4 5 4 7
    18-54 3 98 4 1,744 10 291 3 3 4 26 4 14
    16-52 3 30 4 352 4 92 3 9 4 89 5 38
    14-50 3 112 4 336 8 319 3 3 4 22 4 38
    27-48 3 37 15 154 6 917 3 3 13 35 4 68
    19-72 3 72 7 287 26 423 3 3 4 34 15 351
    GMTe 3.0 45.7 6.3 228.6 9.1 183.0 3.0 3.4 5.4 25.9 6.1 43.5
    95% CIf 3.0g 26.7-78.5 84.3-620 64.7-517 3.5-11.2 5.2-16.1 3.0 3.4-8.5 3.8-9.6 2.5-4.8 9.6-69.6 14.4-131
Group B
    31-57 3 48 4 936 30 349 3 5 32 1,308 9 212
    10-68 8 124 25 754 13 1,746 3 7 45 2,051 9 257
    4-43 3 166 9 580 11 1,525 3 3 4 55 4 56
    20-55 3 132 4 342 12 1,553 3 6 4 13 5 163
    23-63 3 58 32 376 42 2,520 3 19 14 252 179 1,843
    8-45 3 69 9 660 17 2,224 3 5 5 567 8 1,828
    1-37 3 20 68 158 77 398 3 3 37 68 18 71
    GMT 3.5 72 13.2 475 22 1,182 3.0 5.6 12.9 211 12.3 275
    95% CI 2.4-4.9 37-142 4.9-36 272-832 11-44 559-2,500 3.0 3.2-10.0 4.7-35 38-1,160 3.8-40 75-101
a

Vaccine titers were significantly different for group A and group B, namely, preimmunization IgG titer to pertactin (P < 0.03), postimmunization IgG titer to pertactin (P < 0.005), IgA titer to FHA (P < 0.02), and IgA titer to pertactin (P < 0.03).

b

Group A is the group of subjects with unaltered bactericidal activity after immunization with pertussis vaccine. Group B is the group of subjects with altered bactericidal activity after immunization with pertussis vaccine.

c

Pre, preimmunization.

d

Post, postimmunization.

e

GMT, geometric mean titer.

f

95% CI, 95% confidence interval.

g

A value of 3.0 is shown when no variability was observed.