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. Author manuscript; available in PMC: 2017 Feb 3.
Published in final edited form as: Sci Transl Med. 2016 Oct 19;8(361):361ra137. doi: 10.1126/scitranslmed.aag0367

Figure 3. Early anti-CD40L treatment repressed multiple biological pathways involved in inflammation and autoimmunity.

Figure 3

Gene Set Enrichment Analysis (GSEA) showing pathways down-regulated by a single treatment of anti-CD40L at 4 weeks-of–age compared to control. Data derived from whole salivary gland RNA of 24 week-old mice. The heatmaps show expression of the core genes that contribute to pathway enrichment. Red indicates high expression; blue indicates low expression. NES: Normalized enrichment score; FDR: False discovery rate.