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. 2017 Feb 9;2(3):e91079. doi: 10.1172/jci.insight.91079

Figure 6. Calcium and parathyroid hormone (PTH) increased significantly after injection of the calcilytic in WT mice and mice with activating Gα11.

Figure 6

(A–C) Biochemical parameters at baseline and 4 and 24 hours after bolus i.p. injection of the calcilytic NPS 2143 (Drug) at 28 mg/kg or vehicle (Veh) in 9-week-old GNA11WT/WT (n = 14 vehicle, n = 14 calcilytic), GNA11R60C/WT (n = 13 vehicle, n = 13 calcilytic), and GNA11R60C/R60C (n = 6 vehicle, n = 6 calcilytic) mice. (A–C) blood iCa2+, (D–F) serum PTH, (G–I) serum Pi. Data are shown as mean ± SD. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, using Student’s t test).