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. 2017 Feb 9;2(3):e91079. doi: 10.1172/jci.insight.91079

Figure 7. Treatment of mice with single bolus injection of Gα11/q inhibitor (YM-254890).

Figure 7

iCa2+ and parathyroid hormone (PTH) increased in WT and heterozygous GNA11R60C/WT but not homozygous GNA11R60C/R60C mice. Biochemical parameters at baseline and 4 hours after bolus i.p. injection of YM-254890 at 0.15 mg/kg or vehicle in 12-week-old GNA11WT/WT (n = 11 vehicle, n = 11 YM-254890), GNA11R60C/WT (n = 12 vehicle, n = 12 YM-254890), and GNA11R60C/R60C (n = 5 vehicle, n = 5 YM-254890) mice. (A–C) blood iCa2+, (D–F) serum PTH, (G–I) serum Pi. Data are shown as mean ± SD (*P < 0.05, ***P < 0.001, using Student’s t test).