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. 2017 Feb 9;2(3):e88588. doi: 10.1172/jci.insight.88588

Figure 1. 17-HDHA and RvD1 reduce spontaneous B cell IgE production from asthma patients.

Figure 1

(A) PBMCs from asthma or nonasthmatic donors were cultured in 96-well plates for 6 days, and IgE levels in cell culture supernatants were measured by ELISA. (B) PBMCs from 5 asthma patients were pretreated with 17-HDHA or RvD1 and incubated for 6 days. The SPMs were added daily until day 6 when cell culture supernatants were collected to measure IgE levels. Each symbol represents an individual donor and represents means of triplicates. Data were analyzed by repeated-measures 1-way ANOVA with Tukey’s post test, *P ≤ 0.05, ***P ≤ 0.001. PBMC, peripheral blood mononuclear cell; SPM, specialized proresolving mediator.