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. 2017 Feb 9;2(3):e88588. doi: 10.1172/jci.insight.88588

Figure 6. Inhibition of 5-lipoxygenase activity blocks anti-IgE effects of 17-HDHA and RvD1.

Figure 6

CD19+ B cells (A) or PBMCs (B) from a healthy donor were treated with zileuton (10 μM) prior to 17-HDHA or RvD1 treatment, followed by stimulation with the IgE-inducing cocktail. Cell culture supernatants were collected at day 7, and IgE levels were measured. The experiment was done in one representative donor (mean ± SEM). Data were analyzed by 1-way ANOVA with Tukey’s post test, **P ≤ 0.01, ***P ≤ 0.001. PBMC, peripheral blood mononuclear cell.