Figure 5. Effect of NPS-2143 on plasma PTH, calcium, and phosphate of Dsk7 mice at 0, 1, 2, 6, and 24 hours after dose.

(A–C) Plasma PTH, (D–F) plasma adjusted-calcium, and (G–I) plasma phosphate concentrations of WT (+/+), Dsk7/+, and Dsk7/Dsk7 mice, respectively. Mean values for the respective groups are indicated by solid bars. n = 4–7 mice per study time point. Squares, males; circles, females. *P < 0.05, **P < 0.01. A Kruskal-Wallis test followed by Dunn’s test for nonparametric pairwise multiple comparisons were used for analysis of A–I.