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. Author manuscript; available in PMC: 2017 Feb 3.
Published in final edited form as: J Genet Genomics. 2011 Sep 24;38(10):453–460. doi: 10.1016/j.jgg.2011.09.007

Fig. 1.

Fig. 1

PcG and TrxG proteins regulate gene expression by modulating chromatin structures. PcG and TrxG proteins directly methylate specific histone residues to establish repressive (H3K27me3) and active (H3K4me3) histone marks, respectively. In addition, they are able to recruit enzymes that modulate other histone modifications such as acetylation and demethylation as well as DNA methylation. PcG complexes can associate with HDACs, H3K4me3-specific HDMs and DNMTs to suppress gene expression, whereas TrxG complexes recruit HATs and H3K27me3-specific HDMs to activate gene expression.