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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2016 Dec 9;25(3):1004–1013. doi: 10.1016/j.bmc.2016.12.014

Figure 3.

Figure 3

Effect of 8 on expression of natriuretic peptide A and myosin light chain 7 mRNAs in hearts of LmnaH222P/H222P mice. (A) Quantitative real-time RT–PCR analysis of mRNA encoding natriuretic peptide A (Nppa) in hearts from LmnaH222P/H222P mice treated with placebo or 8 at 3 mg/kg/day or 6 mg/kg/day. (B) Quantitative real-time RT–PCR analysis of mRNA encoding myosin light chain 7 (Myl7) in hearts from LmnaH222P/H222P mice treated with placebo or 8 at 3 mg/kg/day or 6 mg/kg/day. Results for placebo treatment (n = 5) are normalized to 1 and those for treatment with 3 mg/kg/day (n = 5) or 6 mg/kg/day (n = 6) of 8 represent as fold change compared to placebo treatment. Bar graphs show means and standard errors. *P<0.05 compared to placebo.