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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2016 Dec 9;25(3):1004–1013. doi: 10.1016/j.bmc.2016.12.014

Figure 4.

Figure 4

Effect of 8 on cardiac fibrosis in LmnaH222P/H222P mice. (A) Photomicrographs of representative left ventricle sections stained with Masson trichrome from LmnaH222P/H222P mice treated with placebo or 8 at 3 mg/kg/day or 6 mg/kg/day. Scale bar: 70 µm. The placebo image corresponds to grade 4 histology (severe fibrosis), the 3 mg/kg image corresponds to grade 2 histology (moderate vacuolation, no fibrosis) and the 6 mg/kg image corresponds to grade 1 histology (mild vacuolation, no fibrosis). (B) Cardiac fibrosis scores for LmnaH222P/H222P mice treated with placebo (n = 5) or 3 mg/kg/day (n = 5) or 6 mg/kg/day (n = 6) of 8. Bar graph shows means and standard errors. *P<0.05, **P<0.01 compared to placebo.