Table 2.
Selected serum chemistry values in LmnaH222P/H222P mice at 20 weeks of age treated for 6 weeks with placebo or 8.
| Treatment | Placebo | 8 (3 mg/kg/day) | 8 ( 6 mg/kg/day) |
|---|---|---|---|
| Alkaline Phosphatase (U/L) | 91.5 ± 6.99 | 104.5 ± 7.43 | 113.0 ± 6.55 |
| ALT (U/L) | 56 ± 10.55 | 69.6 ± 10.81 | 69.6 ± 14.31 |
| Total bilirubin (mg/L) | 0.36 ± 0.02 | 0.32 ± 0.02 | 0.37 ± 0.03 |
| Amylase (U/L) | 1,102 ± 53.63 | 1,372 ± 282.9 | 1,086 ± 40.18 |
| BUN (mg/dL) | 17.98 ± 0.94 | 18.04 ± 0.48 | 19.12 ± 1.83 |
| Creatinine (mg/dL) | 0.45 ± 0.01 | 0.46 ± 0.01 | 0.46 ± 0.01 |
| BUN/Creatinine | 20.14 ± 1.25 | 19.66 ± 0.61 | 20.77 ± 1.92 |
ALT, alanine aminotransferase; BUN, blood urea nitrogen. Values are means ± standard errors for n = 10 mice per group.