Table 3.
Adjusted trajectory and associations of predictors with trajectories of bodily pain in natural menopause.1,2
| Bodily Pain Score at FMP (95% CI) | Annualized Rate of Change in Bodily Pain Score (95% CI) | Mean Change in Bodily Pain Score from 7 years before to 5 years after the FMP (95% CI) | |||
|---|---|---|---|---|---|
| Late Reproductive: 8.8 to 4.5 years before the FMP | Transmenopause: 4.5 years before the FMP to 0.5 years after the FMP | Postmenopause: 0.5-8.4 years after the FMP | |||
| Adjusted mean in referent group3 | 26.47 (23.78, 29.16) | −0.14 (−1.12, 0.83)4 | 0.41 (−0.10, 0.91) | −0.42 (−0.86, 0.01)5 | −0.24 (−2.87, 2.39) |
| Adjusted associations of predictors with trajectory parameters | |||||
| Time-invariant predictors | |||||
| Age at FMP (years) | −0.02 (−0.91, 0.87) | −0.08 (−0.3, 0.15) | 0.07 (−0.04, 0.17) | −0.04 (−0.13, 0.05) | −0.02 (−0.61, 0.58) |
| Race/ethnicity | |||||
| African American | 2.57 (−2.10, 7.23) | 1.14 (−0.07, 2.35) | −0.52 (−1.16, 0.12) | 0.34 (−0.20, 0.89) | 1.81 (−1.44, 5.06) |
| Chinese | 2.87 (−3.78, 9.51) | −0.01 (−1.70,1.69) | 0.64 (−0.25, 1.54) | −0.35 (−1.11, 0.42) | 1.64 (−2.97, 6.25) |
| Japanese | −0.57 (−6.70, 5.56) | −0.15 (−1.71,1.41) | 0.02 (−0.86, 0.89) | 0.19 (−0.58, 0.95) | 0.54 (−3.85, 4.93) |
| Hispanic | −1.48 (−10.52, 7.55) | 1.10 (−1.22, 3.42) | −1.38 (−2.81, 0.05) | −0.77 (−2.21, 0.66) | −7.63 (−14.34, −0.92) |
| Baseline abdominal cramps | −6.14 (−9.83, −2.45) | −1.13 (−2.06, −0.20) | −0.29 (−0.79, 0.22) | 0.05 (−0.39, 0.48) | −4.05 (−6.49, −1.60) |
| Time-varying predictors6 | |||||
| BMI | 0.16 (−0.12, 0.45) | −0.04 (−0.11, 0.04) | 0.07 (0.03, 0.11) | 0.01 (−0.02, 0.05) | 0.32 (0.13, 0.52) |
| Smoking | 1.03 (−1.70, 3.77) | 0.68 (−0.07, 1.42) | −0.42 (−1.16, 0.32) | 0.48 (−0.17, 1.13) | 1.76 (−1.03, 4.54) |
| Depression | 5.27 (2.89, 7.64) | 1.37 (0.72, 2.02) | −0.14 (−0.79, 0.51) | 0.15 (−0.42, 0.72) | 3.39 (0.96, 5.83) |
| Sleep problems | 2.98 (0.83, 5.13) | 1.03 (0.45,1.61) | −0.32 (−0.92, 0.27) | 0.35 (−0.17, 0.86) | 2.52 (0.32, 4.72) |
Abbreviations: FMP, final menstrual period; CI, confidence interval; BMI, body mass index
1399 observations dropped due to missing time-varying covariate data within segments. 8764 observations used in Table 2 analyses.
To calculate the predicted impact of a clinical variable on bodily pain, the β-coefficient associated with that variable is added to the β-coefficient of the referent case. For example, the impact of depression on the change in overall bodily pain was calculated by adding the β-coefficient of 4.37 to the β-coefficient of −0.65 for the referent case. Thus, the SF-36 bodily pain score for a woman with depression and the same age at FMP, race and BMI as the referent case was expected to increase by 3.72 points over the 12 year period (rather than decrease by 0.65 points, as for the referent case).
Referent group: white women with an age at FMP of 51.9 years, mean baseline BMI of 28.2 kg/m2 and no baseline abdominal cramps. Model also adjusted for income and study site.
P-value for test of difference in slopes between segments 1 and 2 in referent group: 0.40
P-value for test of difference in slopes between segments 2 and 3 in referent group: 0.05
For time-varying predictors, the association between change in the predictor over time and contemporaneous change in bodily pain score is also given by the entries in the first column (score at FMP). Only baseline values were modeled to affect slopes.