Table 2.
Dose-Response Evaluation of NAX 810-2 Following IV Bolus Administration to Male CF-1 Mice in the 6 Hz (32 mA) Model of Psychomotor Seizures.
| NAX 810-2 Dose (mg/kg) |
6 Hz (32 mA) Efficacy (# protected / # tested) Test Time (h) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.08 | 0.25 | 0.5 | 0.75 | 1 | 2 | 3 | 4 | 6 | |
| 0.375 | 2/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 1/8 |
| 0.5625 | 1/8 | 2/8 | 3/8 | 4/8 | 3/8 | 1/8 | 0/8 | 0/8 | 0/8 |
| 0.75 | 1/8 | 5/8 | 7/8 | 8/8 | 3/8 | 2/8 | 2/8 | 1/8 | 1/8 |
| 1.5 | 4/8 | 7/8 | 7/8 | 8/8 | 8/8 | 6/8 | 0/8 | 1/8 | 0/8 |
| ED50 (95% CI): 0.7 mg/kg (0.5 – 0.9) | |||||||||
|
| |||||||||
|
Motor Impairment (# impaired / # tested) |
|||||||||
| 0.375 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 |
| 0.5625 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 | 0/8 |
| 0.75 | 0/8 | 1/8 | 0/8 | 2/8 | 1/8 | 0/8 | 0/8 | 0/8 | 0/8 |
| 1.5 | 0/8 | 4/8 | 1/8 | 2/8 | 2/8 | 1/8 | 0/8 | 0/8 | 0/8 |