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Reduction of extracellular and cell-associated A/New Caledonia/20/99 (H1N1) virus yield in MDCK cells by oseltamivir carboxylate (A) and rimantadine (B). Extracellular virus yield (•) was measured as log10 TCID50/0.2 ml of culture supernatant. Cell-associated virus yield (▪) was measured as log10 TCID50/0.2 ml of cell suspension after three rounds of freeze-thawing. Values are the means ± standard deviations for two or three independent assays.
