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. 2017 Jan 13;49(1):e283. doi: 10.1038/emm.2016.123

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The metabolomic analysis of liver tissue and serum samples in different phenotypes of NAFLD. The score plot of the principal component analysis that was derived from the ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) spectra of liver tissues (a) and serum (b), indicating discrimination among different groups. Venn diagram illustrates the distinct and overlapping metabolites and lists of metabolites that commonly changed in different phenotypes of NAFLD in liver tissue (c) and serum samples (d) of the rat model groups.