TABLE 2.

Univariate analysis of virological response according to presence of mutated or wild-type codons at specific sites of the protease gene^a

Site and WTa amino acid	Product(s) of WT or mutated codon	No. of isolates with codon	Mean decrease in VL (SD)	P value (Mann-Whitney)
L10	L	40	−1.5510 (1.19754)	0.003
	I, R, V, F	32	−0.6859 (0.96078)
L24	L	66	−1.2389 (1.19091)	0.080
	I	6	−0.3700 (0.54966)
M46	M	47	−1.4393 (1.23546)	0.018
	I, L	25	−0.6537 (0.85555)
G48	G	67	−1.2332 (1.17802)	0.055
	V	5	−0.2730 (0.70180)
I54	I	56	−1.2920 (1.18422)	0.081
	V	16	−0.7272 (1.05669)
I62	I	52	−1.3745 (1.16537)	0.015
	V	20	−0.6258 (1.03855)
A71	A	43	−1.4158 (1.25267)	0.033
	T, V	29	−0.7970 (0.95081)
V82	V	41	−1.5429 (1.24076)	0.003
	A, F, S, T	31	−0.6687 (0.87138)
I84	I	61	−1.3764 (1.14977)	<0.001
	V	11	−0.0028 (0.30815)
L90	L	53	−1.4675 (1.16881)	0.001
	I, M	19	−0.3271 (0.69214)
T12	T	63	−1.0211 (1.10030)	0.010
	A, D, N, P, Q, S	9	−2.1843 (1.23155)
I13	I	52	−0.9645 (1.10941)	0.038
	V	20	−1.6916 (1.20185)

^aWT, wild-type.