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IC50 data for four rDHFRs
| Enzyme | IC50 (nM)a
|
|
|---|---|---|
| TMP | MTXb | |
| Human rDHFR | 1.62 × 106 ± 5.77 × 103 (2) | 24.3 ± 6.99 (3) |
| B. anthracis Sterne rDHFR | ||
| With His tag | 7.73 × 104 ± 8.24 × 103 (4) | 15.1 ± 2.82 (3) |
| Without His tag | 7.72 × 104 ± 2.04 × 103 (4) | 12.2 ± 3.1 (3) |
| M. avium rDHFR | 5.75 × 103 ± 7.70 × 102 (3) | 5.1 ± 0.83 (5) |
Each value is the mean ± standard error of the mean. The number of samples is given in parentheses.
MTX, methotrexate.
