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. Author manuscript; available in PMC: 2017 Feb 4.
Published in final edited form as: Cerebrovasc Dis. 2014 Jun 26;37(5):382–388. doi: 10.1159/000362590

Figure 1. Accumulation of ischemic and hemorrhagic vascular pathology.

Figure 1

The figure above shows a hypothetical scheme of accumulating vascular brain pathology. In a first stage, subclinical ischemic and hemorrhagic vascular pathology may occur concurrently due to common risk factors or pathophysiological mechanisms (images from left to right: microbleed on T2* weighted sequence; white matter lesions on fluid-attenuated inversion recovery (FLAIR); lacune of presumed vascular origin on FLAIR). In a later stage, a common pathway may diverge into distinct final pathways in which ischemic or hemorrhagic specific risk factors cause one overall clinical phenotype of vascular brain disease.